Giants vs. Brewers odds, line, prediction: 2022 MLB picks, Monday, April 25 best bets from proven model -

It isn't often that a one-game series takes place in Major League Baseball, but that is the case on Monday evening at American Family Field. The Milwaukee Brewers welcome the San Francisco Giants to town for a one-off tilt. The game was previously scheduled for early April as part of a full series, though things were shuffled after the 2022 season was delayed. San Francisco enters at 11-5 this season, and Milwaukee boasts a 10-6 record.

Caesars Sportsbook lists Milwaukee as the -190 money-line favorite (risk $190 to win $100) for this 6:10 p.m. ET first pitch. The total number of runs Vegas thinks will be scored, or the over-under, is seven in the latest Brewers vs. Giants odds. Before making any Giants vs. Brewers picks, you need to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a sizzling start to the 2022 season. It's on a 25-11 roll on top-rated MLB money-line picks through three weeks, returning almost $1,100 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in on Giants vs. Brewers, and just locked in its picks and MLB predictions. You can visit SportsLine now to see the model's picks. Here are the MLB odds and trends for Brewers vs. Giants:

  • Giants vs. Brewers money line: Brewers -190, Giants +170
  • Giants vs. Brewers over-under: 7 runs
  • Giants vs. Brewers run line: Brewers -1.5 (+105)
  • SF: The Giants are 7-3 in road games
  • MIL: The Brewers are 5-2 in home games
Featured Game | Milwaukee Brewers vs. San Francisco Giants

Why you should back the Giants

Plenty of attention will be paid to Milwaukee's starting pitching option, and rightly so, but the Giants also project well in run prevention. San Francisco ranks in the top three of Major League Baseball with a staff ERA of 2.51, and the bullpen is tremendous. The Giants are set to deploy the equivalent of a bullpen game on Monday, though 29-year-old Sam Long will open things up. He has thrown 4.2 innings of scoreless baseball this season across four appearances and, when Long leaves the game, he will be flanked by a Giants relief corps that leads the NL with a 1.71 ERA in 63 innings. 

San Francisco's relievers have a 49.7 percent ground ball rate and have allowed only 0.43 home runs per nine innings. Milwaukee is below-average offensively in the early going, landing below the NL median in batting average, slugging percentage, on-base percentage, home runs and runs scored. On offense, the Giants rank in the top three of the NL with 79 runs scored and 17 home runs. San Francisco is clearly above-average at the plate, and the Giants are coming off a 2021 campaign in which they were near the top of the NL in virtually every offensive category.

Why you should back the Brewers

The Brewers have a patient approach at the plate, producing a walk in nearly 10 percent of plate appearances. Milwaukee also has a strong defensive projection but, more than anything, the Brewers can lean on one of the best starting pitchers on the planet in this matchup. Corbin Burnes, the 2021 Cy Young award winner, takes the ball for Milwaukee, and he led the National League with a 2.43 ERA last season. Burnes also had the best strikeout rate of any National League pitcher, striking out 12.6 batters per innings. 

He also walked only 1.8 batters per nine innings in 2021, and Burnes led the league with 6.88 times as many strikeouts as walks. Beyond that, he is excellent at preventing home runs, leading the league with 0.377 home runs per nine innings, and the 2022 season is also going well for Burnes. Through three starts, he has navigated 19.0 innings with a 2.37 ERA and more than 10 strikeouts per nine innings. That includes 18 strikeouts and only two earned runs allowed in his last 14 innings across two starts.

How to make Brewers vs. Giants picks

SportsLine's model is leaning over on the run total, as the simulation suggests the teams will combine for 7.5 runs. It also says one side of the money line has all the value. You can only get the model's pick at SportsLine

So who wins Giants vs. Brewers? And which side of the money line has all the value? Visit SportsLine now to see which side to jump on, all from the advanced model that has crushed its top-rated MLB picks, and find out.


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